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KMID : 0363220180560030197
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Korean Journal of Dermatology
2018 Volume.56 No. 3 p.197 ~ p.201
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IgG4-related Skin Disease: Experience with Two Cases
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Lee Jin-Hyup
Kim Ji-Young
Lim Seul-Ki
Im Myung
Lee Young
Seo Young-Joon
Lee Jeung-Hoon
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Abstract
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IgG4-related disease (IgG4-RD) is a new disease entity characterized by elevated serum IgG4 and infiltration of IgG4＋ plasma cells in tissue. IgG4-RD can involve various organs, and skin could also be affected. The manifestations of IgG4-related skin disease (IgG4-RSD) are not characteristic, however it usually presents with multiple erythematous nodules or plaques with itching sensation. We report two cases of IgG4-RSD. Histological studies of these cases revealed infiltration of numerous plasma cells and mononuclear cells in the entire dermis. Some plasma cells were strongly positive for IgG4 stain. IgG4-RSD is a treatable disease with systemic corticosteroids. Thus, clinicians should obtain a biopsy and identify IgG4-positive cells for an accurate diagnosis.
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KEYWORD
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IgG4-related disease
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